Peripheral neuropathy
Causes
Demyelinating versus axonal [1]
| Systemic disease | |
| Demyelinating | Axonal |
| Guillan Barre Syn | Diabetic |
| Paraproteinemia (IgM) | Paraneoplastic |
| Critical illness | |
| Paraproteinemia (IgG, IgA) | |
| B12 deficiency | |
| Connective tissue disease | |
| Amyloidosis | |
| Hypothyroidism | |
| Lyme disease | |
| VItamin Deficiency | |
Toxic neuropathy
Hereditary
Idiopathic
Although population-based data are lacking, no specific cause is identified in up to 46 percent of patients with polyneuropathy at referral centers despite extensive investigations A variety of terms have been employed to describe this disorder, including chronic idiopathic axonal polyneuropathy (CIAP), chronic sensory polyneuropathy, chronic polyneuropathy of undetermined cause, unclassified peripheral neuropathy, and idiopathic neuropathy. Most such cases present in adults ≥50 years of age and progress slowly over months to years. The symptoms are typically sensory, involving paresthesia, numbness, or pain. Electrodiagnostic studies show a primarily axonal polyneuropathy. Proposed but unproven causes include impaired glucose tolerance, hypertension, dyslipidemia, and increased oxidative stress. [1]
