Gilbert syndrome

Definition

A hereditary disorder of unconjugated bilirubin production. It is the most common  inherited disorder of bilirubin glucuronidation. It is also known as Meulengracht disease. Gilbert syndrome is a benign condition that has also been called "constitutional hepatic dysfunction" and "familial nonhemolytic jaundice". Although many patients present as isolated cases, the condition can also run in families. It is characterized by recurrent episodes of jaundice and may be triggered by, among other things, dehydration, fasting, intercurrent disease, menstruation, and overexertion. Other than jaundice, patients are typically asymptomatic. The hyperbilirubinemia in patients with Gilbert syndrome is unconjugated. The diagnosis is made by excluding other causes of unconjugated hyperbilirubinemia, though genetic testing is available. No treatment is necessary, though it may be a risk factor for toxicity from some medications. [1]