Angioedema

Angioedema is a swelling of face or limbs that occurs either acutely as a reaction to a medication or food but chronically can occur not uncommonly from an unknown trigger or cause. It can be associated with diseases such has hereditary angieoedma from a C1inhibitor deficiency or rarely associated with  systemic lupus. The "classic" presentation is after use of a type of blood pressure or heart medicine, ACE inhibitors.  Common ACE inhibitors in practice include lisinopril, ramipril and captopril. 

The swelling of angioedema occurs in the deep layers of the skin, often seen with urticaria (hives). Angioedema most often occurs in soft tissues such as the eyelids, mouth or genitals. Chronic recurrent angioedema is when the condition returns over a long period of time. It most often does not have an identifiable cause. Hereditary angiodema (HAE) is a rare, but serious genetic condition involving swelling in various body parts including the hands, feet, face, intestinal wall and airways. [2]

While other conditions are acquired, c-1 inhibitor deficieny is hereditary. [3]

Causes of angioedema

  Medications - ACE inhibitors

C1 inhibitor deficiency

Systemic lupus

Food allergy

Medications - NSAID drugs

Cytoplasmic pattern from ANA Patterns