Rheumatology News

Latest stories relevant to rheumatology patients

The FDA added a warning to use of Prolia (denosumab) an osteoporosis drug about increased cases of low calcium level. Low calcium or hypocalcemia can cause serious heart issues. An increase in this side effect was seen in dialysis patients taking Prolia (H Rosen. Denosumab for osteoporosis . Uptodate 2/5/2024)

The FDA approved Cosentyx (secukinumab) for treatment of hidradenitis suppurativa (HS). HS is a drastic inflammatory skin disease and has long been a challenge to manage. Cosentyx is an injectable drug that inhibits an inflammatory mediator, Interleukin-17. (COSENTYX® Data Highlights Redefine HS treatment with the FIRST and ONLY FDA-approved IL-17A antagonist speaker program, 1/25/2024)

The FDA recalled eyedrops used for dry eyes made by 2 different manufacturers in Jan and Feb 2023. Products made by Global Pharmaceutical (EzriCare) and Delsam Pharma's artificial tears were recalled after cases of serious infection were linked to drops.  (New York Times May 2023)

The first FDA approved drug for polymyalgia rheumatica (PMR) is a subcutaneous bi-monthly injection of a drug already approved for rheumatoid arthritis. It acts by inhitibion of the interleukin-6 receptor. (Pharmacy Times Mar 2023)

In an extension of a 1 year trial called DESIRE, people with systemic sclerosis had improvement in lungs and skin when continuing rituximab for average of 96 weeks. (JAMA Feb 2023)

In a comparison of people with symptoms persisting after Covid, immunology lab was similar to a control group. (Ann Int Med Feb 2023)

In a comparison of holding methotrexate (MTX) 1 week versus 2 weeks there was no difference in response to Flu shots but was more flare of rheumatoid arthritis in the 2 week hold group. So, stop methotrexate just one week after a vaccine.   (Park et al.  Multicenter, Prospective, Randomized, Parallel-Group Trial on the Effects of Temporary Methotrexate Discontinuation for One Week Versus Two Weeks on Seasonal Influenza Vaccination in Patients With Rheumatoid Arthritis. Arthr Rheum Feb 2023)